Syntheses of Saccharin and Cyclamate Derivatives Bearing Polymerizable Vinyl Group
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چکیده
منابع مشابه
Saccharin and cyclamate inhibit binding of epidermal growth factor.
The binding of 125I-labeled mouse epidermal growth factor (EGF) to 18 cell lines, including HeLa (human carcinoma), MDCK (dog kidney cells), HTC (rat hepatoma), K22 (rat liver), HF (human foreskin), GM17 (human skin fibroblasts), XP (human xeroderma pigmentosum fibroblasts), and 3T3-L1 (mouse fibroblasts), was inhibited by saccharin and cyclamate. The human cells were more sensitive to inhibiti...
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In order to investigate the relationship between depth within membranes of singlet oxygen generation and effectiveness of photodynamic therapy of tumors, analogs of protoporphyrin-IX 1 bearing five 4 and seven 5 carbon atoms (in place of the 3-carbon atom chain in 1) were synthesized from monopyrrole precursors.
متن کاملSynthesis of Novel Saccharin Derivatives.
The synthesis of saccharin (1,2-benzisothiazol-3-one-1,1-dioxide) derivatives substituted on the benzene ring has seen limited development despite the longevity of this compound's use as an artificial sweetener. This type of saccharin derivative would however present attractive properties for the development of new bioactive, drug-like small molecule compounds. Here we report the derivatisation...
متن کاملFeeding studies on sodium cyclamate, saccharin and sucrose for carcinogenic and tumour-promoting activity.
Groups of 50 female Swiss mice were fed for 18 months on a standard diet containing sucrose (10 %), sodium cyclamate (5 %) or saccharin (5 %), while 100 control mice were fed on the standard diet alone. The survival times were comparable in all groups and no acute toxic effects were encountered. No local tumours in the gastro-intestinal tract, nor excess incidence of distant tumours, were found...
متن کاملGrowth inhibitory action of saccharin and cyclamate on rats receiving a poor rice diet.
I . The effect of saccharin and cyclamate on growth of young rats fed on a poor rice diet or a balanced diet was investigated. 2. Saccharin and cyclamate retarded the growth of rats on the multi-deficient diet but not of those on the well-balanced diet during an 8-week feeding period. 3. The sweeteners did not produce any macroscopic or microscopic changes in the liver, kidneys, intestines, spl...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1982
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.55.3824